Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 18/20 | 0.65 |
| ▸ | AR | P10275 | 3/20 | 0.58 |
| ▸ | BTK | Q06187 | 2/20 | 0.51 |
| ▸ | HPGDS | O60760 | 2/20 | 0.50 |
| ▸ | DDB1 | Q16531 | 8/20 | 0.49 |
| ▸ | CDK9 | P50750 | 1/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.47 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.47 |
| ▸ | IRAK3 | Q9Y616 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.47 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.47 |
| ▸ | IKZF3 | Q9UKT9 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24206867 | 1.00 | CRBN (0.65) | CRBNARBTKHPGDSDDB1 | |
| SCHEMBL31055547 | 0.95 | CRBN (0.60) | CRBNARBTKHPGDSDDB1 | |
| SCHEMBL24671174 | 0.95 | CRBN (0.60) | CRBNARBTKHPGDSDDB1 | |
| SCHEMBL22326213 | 0.92 | CRBN (0.77) | CRBNHPGDSDDB1ALDH1A1CHRM2 | |
| SCHEMBL26929077 | 0.91 | CRBN (0.65) | CRBNARBTKDDB1CDK9 | |
| SCHEMBL30692989 | 0.91 | CRBN (0.65) | CRBNARBTKDDB1CDK9 | |
| SCHEMBL26969669 | 0.90 | CRBN (0.69) | CRBNARBTKDDB1CDK9 | |
| SCHEMBL27176460 | 0.89 | CRBN (0.65) | CRBNARBTKDDB1CDK9 | |
| SCHEMBL31447732 | 0.89 | CRBN (0.80) | CRBNARBTKDDB1CDK9 | |
| SCHEMBL29927704 | 0.88 | CRBN (0.59) | CRBNARBTKHPGDSDDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4146660-A1 | BIFUNCTIONAL DEGRADERS OF HEMATOPOIETIC PROGENITOR KINASE AND THERAPEUTIC USES THEREOF | Nurix Therapeutics, Inc. (US) | 2023-03-15 | — | — | EP | disclosed |
| WO-2022143856-A1 | DEGRADATION OF BRUTON'S TYROSINE KINASE (BTK) BY CONJUGATION OF BTK INHIBITORS WITH E3 LIGASE LIGAND AND METHODS OF USE | BEIGENE, LTD. (KY) | 2022-07-07 | — | — | WO | disclosed |
| WO-2022068849-A1 | BIFUNCTIONAL COMPOUNDS FOR DEGRADATION OF EGFR AND RELATED METHODS OF USE | BEIGENE, LTD. (KY) | 2022-04-07 | — | — | WO | disclosed |