SCHEMBL24671385

SCHEMBL24671385

N=C(N)NCCc1ccc(NC(=O)c2ccc(C3=CCN(C(=N)N)CC3)cc2F)cc1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
MCHR1 Q99705 2/20 0.42
NAMPT P43490 7/20 0.40
MAPT P10636 4/20 0.39
NPC1 O15118 3/20 0.39
RAB9A P51151 3/20 0.39
ALDH1A1 P00352 2/20 0.39
ALOX15 P16050 2/20 0.39
SMN1; SMN2 Q16637 2/20 0.39
HPGD P15428 1/20 0.39
CASP3 P42574 1/20 0.39
SENP8 Q96LD8 1/20 0.39
SENP7 Q9BQF6 1/20 0.39
SENP6 Q9GZR1 1/20 0.39
LMNA P02545 2/20 0.36
CCNT1 O60563 1/20 0.36
CDK9 P50750 1/20 0.36
HTT P42858 1/20 0.36
NPSR1 Q6W5P4 1/20 0.36
TSHR P16473 1/20 0.36
TP53 P04637 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24670895 0.86 TMPRSS2 (0.44) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24668998 0.83 TMPRSS2 (0.42) MCHR1NAMPTTMPRSS2
SCHEMBL29803078 0.83 TMPRSS2 (0.42) MCHR1NAMPTTMPRSS2
SCHEMBL24891892 0.83 NPC1 (0.40) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24891809 0.83 NPC1 (0.40) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24671333 0.82 MAPT (0.41) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24671165 0.82 ALDH1A1 (0.36) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24667839 0.80 MAPT (0.42) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL29803077 0.80 MAPT (0.42) NAMPTMAPTNPC1RAB9AALDH1A1
SCHEMBL24670299 0.80 MAPT (0.46) NAMPTMAPTNPC1RAB9AALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO claimed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed
WO-2022192162-A1 NOVEL HETEROAROMATIC COMPOUNDS EXHIBITING ANTIFUNGAL ACTIVITY AND THEIR METHOD OF USE FOX CHASE CHEMICAL DIVERSITY CENTER, INC. (US) 2022-09-15 WO disclosed