Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 2/20 | 0.45 |
| ▸ | HTR2A | P28223 | 1/20 | 0.43 |
| ▸ | HTR2C | P28335 | 1/20 | 0.43 |
| ▸ | HTR2B | P41595 | 1/20 | 0.43 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | ANPEP | P15144 | 2/20 | 0.37 |
| ▸ | DPP4 | P27487 | 2/20 | 0.37 |
| ▸ | MEN1 | O00255 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 2/20 | 0.33 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17517182 | 0.82 | IDH1 (0.46) | IDH1HTR2CKMT2AGRM5GRM1 | |
| SCHEMBL17517176 | 0.79 | IDH1 (0.46) | IDH1MEN1KMT2AGRM1 | |
| SCHEMBL7952458 | 0.79 | IDH1 (0.46) | IDH1HTR2BDPP4MEN1KMT2A | |
| SCHEMBL24670531 | 0.79 | IDH1 (0.46) | IDH1HTR2CHTR2BANPEPDPP4 | |
| SCHEMBL17517149 | 0.79 | MAPK1 (0.48) | IDH1MEN1KMT2AGRM5GRM1 | |
| SCHEMBL23371756 | 0.78 | HTR2A (0.46) | HTR2AHTR2CHTR2BCRHBPCRHR2 | |
| SCHEMBL7680451 | 0.78 | ALOX15 (0.45) | HTR2AHTR2CHTR2BMEN1KMT2A | |
| SCHEMBL29951946 | 0.76 | IDH1 (0.44) | IDH1MEN1KMT2AGRM5 | |
| SCHEMBL17517174 | 0.76 | IDH1 (0.44) | IDH1GRM5GRM1 | |
| SCHEMBL17517157 | 0.76 | UGCG (0.49) | IDH1HTR2AHTR2CHTR2BMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022235715-A1 | COMPOUNDS FOR INHIBITING OR DEGRADING ITK, COMPOSITIONS, COMPRISING THE SAME METHODS OF THEIR MAKING AND METHODS OF THEIR USE | NURIX THERAPEUTICS, INC. (US) | 2022-11-10 | — | — | WO | disclosed |