Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NT5E | P21589 | 8/20 | 0.68 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.55 |
| ▸ | LMNA | P02545 | 2/20 | 0.55 |
| ▸ | POLB | P06746 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | PDE2A | O00408 | 1/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.50 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | ATG7 | O95352 | 1/20 | 0.47 |
| ▸ | ADK | P55263 | 3/20 | 0.45 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20305379 | 0.90 | PDE2A (0.61) | NT5ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL18483533 | 0.86 | SMN1; SMN2 (0.55) | NT5ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL22614532 | 0.81 | NT5E (1.00) | NT5E | |
| SCHEMBL22975822 | 0.81 | NT5E (1.00) | NT5E | |
| SCHEMBL27195120 | 0.81 | NT5E (0.54) | NT5EADORA3 | |
| SCHEMBL30008411 | 0.81 | NT5E (0.54) | NT5EADORA3 | |
| SCHEMBL22704891 | 0.81 | SMN1; SMN2 (0.54) | NT5ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL6674410 | 0.81 | SMN1; SMN2 (0.54) | NT5ESMN1; SMN2LMNAPOLBALDH1A1 | |
| SCHEMBL1737936 | 0.81 | ATG7 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1ADORA3 | |
| SCHEMBL29325550 | 0.81 | ATG7 (0.69) | SMN1; SMN2LMNAPOLBALDH1A1ADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024010810-A2 | FC CONJUGATES INCLUDING AN INHIBITOR OF CD73 AND USES THEREOF | CIDARA THERAPEUTICS, INC. (US) | 2024-01-11 | — | — | WO | disclosed |
| WO-2022237747-A1 | SMALL MOLECULAR CD73 ANTAGONIST AND USE THEREOF | 四川海思科制药有限公司 | 2022-11-17 | — | — | WO | disclosed |