Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRMT5 | O14744 | 1/20 | 0.80 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.80 |
| ▸ | AHCY | P23526 | 10/20 | 0.56 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.56 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.56 |
| ▸ | DPP4 | P27487 | 1/20 | 0.56 |
| ▸ | MEN1 | O00255 | 1/20 | 0.56 |
| ▸ | SLC28A1 | O00337 | 1/20 | 0.56 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.56 |
| ▸ | SLC28A2 | O43868 | 1/20 | 0.56 |
| ▸ | GAPDH | P04406 | 1/20 | 0.56 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.56 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.56 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.56 |
| ▸ | STAT6 | P42226 | 1/20 | 0.56 |
| ▸ | PI4KA | P42356 | 1/20 | 0.56 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.56 |
| ▸ | DOT1L | Q8TEK3 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24673475 | 1.00 | PRMT5 (0.80) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL24673580 | 1.00 | PRMT5 (0.80) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL24673581 | 1.00 | PRMT5 (0.80) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL24673573 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL22797623 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL22799077 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL24673967 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL24673534 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL22797656 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B | |
| SCHEMBL22797659 | 0.89 | PRMT5 (1.00) | PRMT5WDR77AHCYADORA2AADORA2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | JANSSEN PHARMACEUTICA NV (BE) | 2022-09-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220275018-A1 | NOVEL SPIROBICYCLIC INTERMEDIATES | NME2, SLC28A1, SLC28A2 | PRMT5 3663/4885WDR77 3289/4885AHCY 998/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.