Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | HTT | P42858 | 3/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 2/20 | 0.31 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.31 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24607218 | 0.91 | HTT (0.35) | KDM4EALDH1A1HTTTDP1MEN1 | |
| SCHEMBL25886631 | 0.88 | CARM1 (0.33) | HTT | |
| SCHEMBL24672987 | 0.86 | KDM4E (0.42) | KDM4EALDH1A1HTTTDP1POLB | |
| SCHEMBL23696532 | 0.86 | KDM4E (0.42) | KDM4EALDH1A1HTTTDP1POLB | |
| SCHEMBL25477793 | 0.84 | ALDH1A1 (0.40) | KDM4EALDH1A1TDP1POLBUSP2 | |
| SCHEMBL20332947 | 0.82 | ACE2 (0.39) | KDM4EALDH1A1USP2 | |
| SCHEMBL26280140 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1HTTTDP1POLB | |
| SCHEMBL23695903 | 0.81 | ALDH1A1 (0.45) | KDM4EALDH1A1HTTTDP1POLB | |
| SCHEMBL22856155 | 0.80 | HTT (0.32) | HTT | |
| SCHEMBL24572500 | 0.79 | ALDH1A1 (0.43) | KDM4EALDH1A1TDP1POLBUSP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-27 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | IRAK2, IRAK3, IRAK1 | KDM4E 190/4885ALDH1A1 2776/4885HTT 2464/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.