⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25725952 | 0.91 | LMNA (0.31) | — | |
| SCHEMBL23945540 | 0.89 | — | — | |
| SCHEMBL25725963 | 0.88 | MEN1 (0.31) | — | |
| SCHEMBL23946026 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL21673618 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL25729725 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL23471281 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL23945541 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL23945537 | 0.85 | LMNA (0.37) | — | |
| SCHEMBL12859350 | 0.83 | LMNA (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11807636-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-11807636-B2 | IRAK degraders and uses thereof | KYMERA THERAPEUTICS, INC. (US) | 2023-11-07 | — | — | US | disclosed |
| US-20230144292-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2023-05-11 | — | — | US | disclosed |
| US-20220340570-A1 | IRAK DEGRADERS AND USES THEREOF | KYMERA THERAPEUTICS, INC. | 2022-10-27 | — | — | US | disclosed |