Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 16/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.43 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.43 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.43 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2467270 | 0.98 | MET (0.53) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2466972 | 0.95 | MET (0.50) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2468137 | 0.92 | MET (0.53) | MET | |
| SCHEMBL2468870 | 0.90 | MET (0.46) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2492883 | 0.90 | MET (0.49) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2464380 | 0.89 | MET (0.63) | MET | |
| SCHEMBL2496053 | 0.89 | MET (0.44) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2466035 | 0.88 | MET (0.45) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2496076 | 0.88 | MET (0.47) | METPDE4APDE4BPDE4CPDE4D | |
| SCHEMBL2468886 | 0.88 | MET (0.50) | METPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8173653-B2 | Pyridiazinone derivatives for the treatment of tumours | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2012-05-08 | — | — | US | claimed |
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |