Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.63 |
| ▸ | CDK1 | P06493 | 1/20 | 0.59 |
| ▸ | CDK2 | P24941 | 1/20 | 0.59 |
| ▸ | CDK8 | P49336 | 1/20 | 0.59 |
| ▸ | SRC | P12931 | 6/20 | 0.58 |
| ▸ | ABL1 | P00519 | 5/20 | 0.58 |
| ▸ | FLT1 | P17948 | 2/20 | 0.55 |
| ▸ | FLT4 | P35916 | 2/20 | 0.55 |
| ▸ | KIT | P10721 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 7/20 | 0.51 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469544 | 0.93 | KDR (0.65) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL2437488 | 0.90 | KDR (0.78) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL2465036 | 0.88 | KDR (0.56) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL2473024 | 0.85 | KDR (0.76) | KDRFLT1FLT4KITRET | |
| SCHEMBL2471571 | 0.85 | KDR (0.65) | KDRFLT1FLT4KITRET | |
| SCHEMBL2436227 | 0.84 | KDR (0.70) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL10301389 | 0.84 | SRC (0.60) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL2435727 | 0.84 | KDR (0.56) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL2465925 | 0.84 | KDR (0.65) | KDRCDK1CDK2CDK8SRC | |
| SCHEMBL30151207 | 0.83 | KDR (0.57) | KDRCDK1CDK2CDK8SRC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371822-A1 | Heterobicyclic carboxamides as inhibitors for kinases | Novartis AG (CH) | 2011-10-05 | — | — | EP | claimed |