Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 5/20 | 0.78 |
| ▸ | CDK1 | P06493 | 1/20 | 0.74 |
| ▸ | CDK2 | P24941 | 1/20 | 0.74 |
| ▸ | CDK8 | P49336 | 1/20 | 0.74 |
| ▸ | FLT1 | P17948 | 3/20 | 0.70 |
| ▸ | FLT4 | P35916 | 3/20 | 0.70 |
| ▸ | RET | P07949 | 6/20 | 0.64 |
| ▸ | KIT | P10721 | 4/20 | 0.64 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.64 |
| ▸ | SRC | P12931 | 5/20 | 0.58 |
| ▸ | ABL1 | P00519 | 4/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469544 | 0.91 | KDR (0.65) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL2467463 | 0.90 | KDR (0.63) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL2436227 | 0.89 | KDR (0.70) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL1324080 | 0.88 | CDK1 (0.72) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL1324760 | 0.88 | CDK1 (0.72) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL10301389 | 0.86 | SRC (0.60) | KDRCDK1CDK2CDK8RET | |
| SCHEMBL2465925 | 0.85 | KDR (0.65) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL3676641 | 0.85 | CDK2 (1.00) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL29678277 | 0.85 | CDK2 (1.00) | KDRCDK1CDK2CDK8FLT1 | |
| SCHEMBL1324041 | 0.85 | CDK1 (0.72) | KDRCDK1CDK2CDK8FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8026247-B2 | Bicyclic amides as kinase inhibitors | NOVARTIS AG (CH) | 2011-09-27 | — | — | US | disclosed |