Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 2/20 | 0.40 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.38 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | CNR2 | P34972 | 1/20 | 0.38 |
| ▸ | PRSS1 | P07477 | 4/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15131216 | 0.83 | KDM4E (0.38) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL24675507 | 0.80 | TSHR (0.46) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL15924994 | 0.79 | DRD2 (0.51) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL12810301 | 0.79 | TSHR (0.59) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| Hydrochloric Acid SCHEMBL11737462 | 0.79 | KCNA3 (0.52) | KDM4EALDH1A1LMNASMN1; SMN2TSHR | |
| SCHEMBL26696139 | 0.77 | TSHR (0.53) | KDM4ESMN1; SMN2TSHRCYSLTR2CYSLTR1 | |
| SCHEMBL24675826 | 0.77 | GGPS1 (0.40) | TSHRPRSS1 | |
| SCHEMBL24675600 | 0.77 | GGPS1 (0.40) | TSHRPRSS1 | |
| SCHEMBL24674860 | 0.77 | GGPS1 (0.40) | TSHRPRSS1 | |
| Hydrochloric Acid SCHEMBL28661273 | 0.76 | TSHR (0.51) | KDM4ESMN1; SMN2TSHRCYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |