SCHEMBL24675321

SCHEMBL24675321

N#CB1CCN2c3ncc(C#N)cc3OCCC2C1

nearest known ligand 0.34

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
GRM5 P41594 1/20 0.34
NLRP3 Q96P20 2/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL24675011 0.84 TIPARP (0.38)
SCHEMBL24674706 0.78 HTR2A (0.42)
SCHEMBL24640838 0.77 NLRP3 (0.36) GRM5NLRP3
SCHEMBL24640371 0.77 NLRP3 (0.36) GRM5NLRP3
SCHEMBL24639390 0.75 SOS1 (0.37) GRM5NLRP3
SCHEMBL24675530 0.72 TIPARP (0.41)
SCHEMBL24639509 0.72 KRAS (0.42)
SCHEMBL24639511 0.72 KRAS (0.42)
SCHEMBL24639529 0.72 KRAS (0.42)
SCHEMBL24763651 0.68 HTR2A (0.41)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022223022-A1 FUSED-RING HETEROCYCLE DERIVATIVE AND MEDICAL APPLICATION THEREOF 四川海思科制药有限公司 2022-10-27 WO disclosed