Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYSLTR2 | Q9NS75 | 4/20 | 0.54 |
| ▸ | CYSLTR1 | Q9Y271 | 4/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.45 |
| ▸ | MEN1 | O00255 | 1/20 | 0.45 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.44 |
| ▸ | PLA2G4B | P0C869 | 1/20 | 0.44 |
| ▸ | FABP1 | P07148 | 1/20 | 0.43 |
| ▸ | CNR2 | P34972 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | CNR1 | P21554 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675410 | 1.00 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675791 | 1.00 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675240 | 0.95 | CYSLTR2 (0.54) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675778 | 0.88 | SMN1; SMN2 (0.45) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675494 | 0.88 | SMN1; SMN2 (0.45) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675493 | 0.88 | SMN1; SMN2 (0.45) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675626 | 0.88 | SMN1; SMN2 (0.49) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675627 | 0.88 | SMN1; SMN2 (0.49) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675467 | 0.88 | SMN1; SMN2 (0.49) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 | |
| SCHEMBL24675246 | 0.86 | ALDH1A1 (0.45) | CYSLTR2CYSLTR1SMN1; SMN2KDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |