Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 1/20 | 0.45 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.44 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.41 |
| ▸ | SMPD1 | P17405 | 3/20 | 0.39 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.39 |
| ▸ | CNR2 | P34972 | 1/20 | 0.39 |
| ▸ | CNR1 | P21554 | 1/20 | 0.39 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24675778 | 0.95 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675591 | 0.95 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL25828664 | 0.95 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675493 | 0.95 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675494 | 0.95 | SMN1; SMN2 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675246 | 0.95 | ALDH1A1 (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675470 | 0.88 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675798 | 0.88 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675471 | 0.88 | KDM4E (0.45) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 | |
| SCHEMBL24675854 | 0.88 | KDM4E (0.46) | ALDH1A1SMN1; SMN2KDM4ELMNACYSLTR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022159688-A9 | DEGRADERS OF GRK2 AND USES THEREOF | SONATA THERAPEUTICS, INC. (US) | 2023-09-21 | — | — | WO | disclosed |
| WO-2023129564-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2023-07-06 | — | — | WO | disclosed |
| WO-2022159688-A1 | DEGRADERS OF GRK2 AND USES THEREOF | CYGNAL THERAPEUTICS, INC. (US) | 2022-07-28 | — | — | WO | disclosed |