SCHEMBL24676486

SCHEMBL24676486

N#CC1=C(C#N)N=C=N1

nearest known ligand 0.00

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1993425 0.48 MAPK1 (0.43)
SCHEMBL57168 0.47 ALDH1A1 (0.47)
Water SCHEMBL28206588 0.38
Water SCHEMBL28491096 0.38
Water SCHEMBL28277038 0.38
Water SCHEMBL1498163 0.38
Water SCHEMBL28811833 0.38
Water SCHEMBL1325168 0.38
Water SCHEMBL31186927 0.38
Water SCHEMBL12002712 0.38

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 27 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023235376-A1 PROCESS FOR PREPARING 1-(4-CHLOROBENZYL)-1H-IMIDAZOLE-4,5-DICARBOXAMIDE ZOETIS SERVICES LLC (US) 2023-12-07 WO claimed
EP-2183225-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS Rigel Pharmaceuticals, Inc. (US) 2010-05-12 EP claimed
WO-2009012421-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2009-01-22 WO claimed
EP-4399301-A1 MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES AND USES THEREOF Aligos Therapeutics, Inc. (US) 2024-07-17 EP disclosed
WO-2023235376-A1 PROCESS FOR PREPARING 1-(4-CHLOROBENZYL)-1H-IMIDAZOLE-4,5-DICARBOXAMIDE ZOETIS SERVICES LLC (US) 2023-12-07 WO disclosed
EP-4168407-A1 BRAF DEGRADERS C4 Therapeutics, Inc. (US) 2023-04-26 EP disclosed
WO-2023039076-A1 MODIFIED SHORT INTERFERING NUCLEIC ACID (SINA) MOLECULES AND USES THEREOF ALIGOS THERAPEUTICS, INC. (US) 2023-03-16 WO disclosed
EP-3559008-B1 COMPOUNDS BASED ON A BORON-GROUP ELEMENT AND THEIR USE IN ELECTROLYTE COMPOSITIONS SCE FRANCE (FR) 2022-11-02 EP disclosed
EP-3980437-A1 UNA AMIDITES AND USES THEREOF Avidity Biosciences, Inc. (US) 2022-04-13 EP disclosed
WO-2021255212-A1 BRAF DEGRADERS F. HOFFMANN-LA ROCHE AG (CH) 2021-12-23 WO disclosed
WO-2020247818-A1 UNA AMIDITES AND USES THEREOF AVIDITY BIOSCIENCES, INC. (US) 2020-12-10 WO disclosed
WO-2019046500-A1 CYCLIC DINUCLEOTIDES AS ANTICANCER AGENTS BRISTOL-MYERS SQUIBB COMPANY (US) 2019-03-07 WO disclosed
WO-2018176134-A1 SALTS FOR USE IN ELECTROLYTE COMPOSITIONS OR AS ELECTRODE ADDITIVES HYDRO-QUéBEC (CA) 2018-10-04 WO disclosed
EP-2183225-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS Rigel Pharmaceuticals, Inc. (US) 2010-05-12 EP disclosed
WO-2010006096-A1 PROCESSES FOR THE PREPARATION OF ANTI-VIRAL COMPOUNDS AND COMPOSITIONS CONTAINING THEM SMITHKLINE BEECHAM CORPORATION (US) 2010-01-14 WO disclosed
WO-2009012421-A1 CYCLIC AMINE SUBSTITUTED PYRIMIDINEDIAMINES AS PKC INHIBITORS RIGEL PHARMACEUTICALS, INC. (US) 2009-01-22 WO disclosed
EP-0573218-B1 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use SANKYO CO (JP) 2001-03-07 EP disclosed
US-5646171-A HYPOTENSIVE AGENTS SANKYO COMPANY, LIMITED (JP) 1997-07-08 US disclosed
US-5616599-A HYPOTENSIVE AGENTS FOR CARDIOVASCULAR DISORDER SANKYO COMPANY, LIMITED (JP) 1997-04-01 US disclosed
EP-0573218-A2 4-Carboxyimidazoles as angiotensin II antagonists and their thrapeutic use SANKYO COMPANY LIMITED (JP) 1993-12-08 EP disclosed