SCHEMBL24676543

SCHEMBL24676543

Fc1cnc(Cl)nc1-c1sc(C2CCC3(CC2)OCCO3)nc1C(F)(F)F

nearest known ligand 0.31

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
TRPV3 Q8NET8 1/20 0.31
MAPK1 P28482 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29754896 1.00 TRPV3 (0.31) TRPV3MAPK1
SCHEMBL24676727 0.82 KMT2A (0.30)
SCHEMBL29754958 0.81 ATF1 (0.31) MAPK1
SCHEMBL24676744 0.81 ATF1 (0.31) MAPK1
SCHEMBL24676755 0.77 CDK4 (0.35) MAPK1
SCHEMBL29754866 0.77
SCHEMBL24676975 0.77
SCHEMBL29754835 0.76 CDK2 (0.49)
SCHEMBL24676549 0.76 CDK2 (0.49)
SCHEMBL24676513 0.76

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2022155941-A1 CDK2 INHIBITORS QILU REGOR THERAPEUTICS INC. (CN) 2022-07-28 WO disclosed