Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK2 | Q92630 | 6/20 | 0.44 |
| ▸ | IDH1 | O75874 | 1/20 | 0.42 |
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | CDK4 | P11802 | 2/20 | 0.42 |
| ▸ | CCND1 | P24385 | 2/20 | 0.42 |
| ▸ | CCND3 | P30281 | 1/20 | 0.42 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.42 |
| ▸ | CDK2 | P24941 | 2/20 | 0.40 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 1/20 | 0.40 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | DNMT3A | Q9Y6K1 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24676593 | 0.92 | DYRK2 (0.43) | DYRK2IDH1IDH2CDK4CCND1 | |
| SCHEMBL24676591 | 0.90 | DYRK2 (0.41) | DYRK2IDH1IDH2CDK4CCND1 | |
| SCHEMBL24676828 | 0.88 | MAPK1 (0.36) | DYRK2IDH1IDH2CDK4CCND1 | |
| SCHEMBL24676489 | 0.84 | CDK2 (0.55) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL24676490 | 0.82 | CDK2 (0.37) | CDK4CCND1CCND3CDK6CDK2 | |
| SCHEMBL24676928 | 0.81 | CDK4 (0.36) | DYRK2IDH1IDH2CDK4CCND1 | |
| SCHEMBL29754914 | 0.81 | CDK4 (0.36) | DYRK2IDH1IDH2CDK4CCND1 | |
| SCHEMBL24676684 | 0.81 | CDK2 (0.43) | DYRK2IDH1CDK4CCND1CCND3 | |
| SCHEMBL24677048 | 0.79 | CDK2 (0.48) | DYRK2CDK4CCND1CCND3CDK6 | |
| SCHEMBL29754987 | 0.79 | MAPK1 (0.36) | DYRK2IDH1IDH2CDK4CCND1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155941-A1 | CDK2 INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2022-07-28 | — | — | WO | disclosed |