Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.48 |
| ▸ | DRD1 | P21728 | 8/20 | 0.43 |
| ▸ | DRD2 | P14416 | 8/20 | 0.43 |
| ▸ | DRD3 | P35462 | 8/20 | 0.43 |
| ▸ | DRD5 | P21918 | 7/20 | 0.43 |
| ▸ | DRD4 | P21917 | 5/20 | 0.43 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.39 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.39 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.39 |
| ▸ | METAP1 | P53582 | 2/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | BCL2 | P10415 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4640481 | 0.80 | KDM1A (0.61) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL1495858 | 0.76 | KDM1A (0.53) | KDM1ADRD1DRD2DRD3DRD5 | |
| Hydrochloric Acid SCHEMBL23421993 | 0.73 | KDM1A (0.50) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL14158486 | 0.73 | BACE1 (0.37) | DRD1DRD2DRD3DRD5SLC6A2 | |
| SCHEMBL31650219 | 0.71 | KDM1A (0.58) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL23421994 | 0.71 | KDM1A (0.48) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL5749365 | 0.71 | KDM1A (0.58) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL29051650 | 0.70 | HTR2C (0.53) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL577378 | 0.69 | DRD1 (0.62) | KDM1ADRD1DRD2DRD3DRD5 | |
| SCHEMBL31028084 | 0.69 | DRD1 (0.62) | DRD1DRD2DRD3DRD5DRD4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2023-05-11 | — | — | US | disclosed |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | CHUGAI SEIYAKU KABUSHIKI KAISHA (JP) | 2022-09-29 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20230142119-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | KDM1A 1270/4885DRD1 1227/4885DRD2 1561/4885 |
| US-20220306578-A1 | TETRACYCLIC COMPOUND | ALK, TTR, ACVR1 | KDM1A 1270/4885DRD1 1227/4885DRD2 1561/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.