Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK2 | P24941 | 16/20 | 0.39 |
| ▸ | CCNE1 | P24864 | 13/20 | 0.39 |
| ▸ | CDK1 | P06493 | 11/20 | 0.39 |
| ▸ | CCNB1 | P14635 | 11/20 | 0.39 |
| ▸ | CDK7 | P50613 | 10/20 | 0.39 |
| ▸ | CCNH | P51946 | 10/20 | 0.39 |
| ▸ | CCNT1 | O60563 | 10/20 | 0.39 |
| ▸ | CDK9 | P50750 | 10/20 | 0.39 |
| ▸ | CDK4 | P11802 | 9/20 | 0.39 |
| ▸ | CCND1 | P24385 | 9/20 | 0.39 |
| ▸ | CCND3 | P30281 | 9/20 | 0.39 |
| ▸ | CDK6 | Q00534 | 9/20 | 0.39 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.39 |
| ▸ | JUN | P05412 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.37 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.37 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 1/20 | 0.32 |
| ▸ | CCNK | O75909 | 2/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24676822 | 0.90 | CDK2 (0.41) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24675968 | 0.89 | CDK2 (0.36) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24676693 | 0.88 | CDK2 (0.38) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL29754879 | 0.87 | CCNE1 (0.47) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24676443 | 0.87 | CCNE1 (0.47) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24676855 | 0.84 | CDK2 (0.39) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24676939 | 0.81 | CDK4 (0.42) | CDK2CDK1CCNB1CDK7CCNH | |
| SCHEMBL24676105 | 0.81 | CDK2 (0.36) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24677039 | 0.81 | CDK6 (0.37) | CDK2CCNE1CDK1CCNB1CDK7 | |
| SCHEMBL24675989 | 0.78 | CDK2 (0.37) | CDK2CCNE1CDK1CCNB1CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022155941-A1 | CDK2 INHIBITORS | QILU REGOR THERAPEUTICS INC. (CN) | 2022-07-28 | — | — | WO | disclosed |