Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH1 | O75874 | 1/20 | 0.39 |
| ▸ | BRD4 | O60885 | 1/20 | 0.37 |
| ▸ | BRD2 | P25440 | 1/20 | 0.37 |
| ▸ | IL1B | P01584 | 2/20 | 0.36 |
| ▸ | NAMPT | P43490 | 3/20 | 0.35 |
| ▸ | MME | P08473 | 1/20 | 0.31 |
| ▸ | ACE | P12821 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 3/20 | 0.30 |
| ▸ | NAAA | Q02083 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12840777 | 0.94 | NAMPT (0.40) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL14684463 | 0.94 | NAMPT (0.40) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL12797531 | 0.94 | NAMPT (0.40) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL19559437 | 0.87 | — | — | |
| SCHEMBL6338704 | 0.87 | — | — | |
| SCHEMBL25589897 | 0.80 | IDH1 (0.37) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL25590938 | 0.79 | IDH1 (0.44) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL2464736 | 0.77 | NAMPT (0.43) | IDH1IL1BNAMPTMMEACE | |
| SCHEMBL27749157 | 0.76 | IDH1 (0.38) | IDH1BRD4BRD2IL1BNAMPT | |
| SCHEMBL14178991 | 0.75 | NOS3 (0.37) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023116934-A1 | KRASG12D PROTEIN HYDROLYSIS REGULATOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 苏州泽璟生物制药股份有限公司 | 2023-06-29 | — | — | WO | disclosed |
| WO-2022188819-A1 | SOS1 PROTEOLYSIS MODULATOR, PREPARATION METHOD THEREFOR AND APPLICATION THEREOF | 苏州泽璟生物制药股份有限公司 | 2022-09-15 | — | — | WO | disclosed |