Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKCI | P41743 | 4/20 | 0.50 |
| ▸ | AXL | P30530 | 3/20 | 0.50 |
| ▸ | CCNK | O75909 | 2/20 | 0.37 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.37 |
| ▸ | NUDT1 | P36639 | 6/20 | 0.37 |
| ▸ | JAK2 | O60674 | 2/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.36 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.36 |
| ▸ | IKBKB | O14920 | 1/20 | 0.36 |
| ▸ | CHUK | O15111 | 1/20 | 0.36 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.36 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.36 |
| ▸ | PAK4 | O96013 | 1/20 | 0.36 |
| ▸ | CSF1R | P07333 | 1/20 | 0.36 |
| ▸ | RET | P07949 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 1/20 | 0.36 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.36 |
| ▸ | PRKACA | P17612 | 1/20 | 0.36 |
| ▸ | FLT1 | P17948 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30084214 | 1.00 | PRKCI (0.50) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL24678205 | 0.85 | PRKCI (0.47) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL30084209 | 0.85 | PRKCI (0.47) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL30084261 | 0.82 | AXL (0.50) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL24678401 | 0.82 | AXL (0.50) | PRKCIAXLCCNKCDK12JAK2 | |
| SCHEMBL24678765 | 0.81 | PRKCI (0.43) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL30084234 | 0.81 | PRKCI (0.43) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL24678194 | 0.81 | PRKCI (0.54) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL30084188 | 0.81 | PRKCI (0.54) | PRKCIAXLCCNKCDK12NUDT1 | |
| SCHEMBL24678409 | 0.81 | PRKCI (0.49) | PRKCIAXLCCNKCDK12NUDT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022247676-A1 | COMPOUND WITH DIPYRROLOPYRIDINE STRUCTURE, AND PREPARATION METHOD THEREFOR AND MEDICAL USE THEREOF | 南京康屹生物医药中心(有限合伙) | 2022-12-01 | — | — | WO | disclosed |
| CN-115385911-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 南京康屹生物医药中心(有限合伙) | 2022-11-25 | — | — | CN | disclosed |
| CN-113292561-A | Compound with dipyrrolopyridine structure, preparation method and medical application | 中国药科大学 | 2021-08-24 | — | — | CN | disclosed |