Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 4/20 | 0.52 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.44 |
| ▸ | TBK1 | Q9UHD2 | 1/20 | 0.44 |
| ▸ | PIK3C3 | Q8NEB9 | 3/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 2/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.42 |
| ▸ | MAPKAPK5 | Q8IW41 | 2/20 | 0.41 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.41 |
| ▸ | AKT1 | P31749 | 1/20 | 0.40 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.40 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914389 | 1.00 | MTOR (0.52) | MTORMAPKAPK2MAPK1FYNTBK1 | |
| SCHEMBL24680707 | 0.91 | MAPK1 (0.57) | MTORMAPKAPK2MAPK1FYNPIK3C3 | |
| SCHEMBL29914407 | 0.91 | MAPK1 (0.57) | MTORMAPKAPK2MAPK1FYNPIK3C3 | |
| SCHEMBL24681624 | 0.91 | MAPK1 (0.57) | MTORMAPKAPK2MAPK1FYNPIK3C3 | |
| SCHEMBL24680882 | 0.91 | MAPK1 (0.57) | MTORMAPKAPK2MAPK1FYNPIK3C3 | |
| SCHEMBL29914434 | 0.91 | MAPK1 (0.57) | MTORMAPKAPK2MAPK1FYNPIK3C3 | |
| SCHEMBL24680785 | 0.86 | FYN (0.46) | MTORMAPK1FYNTGFBR1ACVR1 | |
| SCHEMBL24681470 | 0.82 | MAPK1 (0.53) | MTORMAPKAPK2MAPK1PIK3C3AKT1 | |
| SCHEMBL24680817 | 0.82 | MAPK1 (0.53) | MTORMAPKAPK2MAPK1PIK3C3AKT1 | |
| SCHEMBL24680816 | 0.82 | MAPK1 (0.53) | MTORMAPKAPK2MAPK1PIK3C3AKT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |