Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.57 |
| ▸ | MTOR | P42345 | 3/20 | 0.45 |
| ▸ | FYN | P06241 | 2/20 | 0.43 |
| ▸ | AKT1 | P31749 | 1/20 | 0.42 |
| ▸ | MAPKAPK2 | P49137 | 6/20 | 0.42 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.42 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.42 |
| ▸ | PIK3C3 | Q8NEB9 | 2/20 | 0.41 |
| ▸ | PARP10 | Q53GL7 | 1/20 | 0.40 |
| ▸ | PARP11 | Q9NR21 | 1/20 | 0.40 |
| ▸ | ALOX5AP | P20292 | 1/20 | 0.40 |
| ▸ | FEN1 | P39748 | 1/20 | 0.40 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914407 | 1.00 | MAPK1 (0.57) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL24680707 | 1.00 | MAPK1 (0.57) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL24681624 | 1.00 | MAPK1 (0.57) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL24680882 | 1.00 | MAPK1 (0.57) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL29914389 | 0.91 | MTOR (0.52) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL24680702 | 0.91 | MTOR (0.52) | MAPK1MTORFYNAKT1MAPKAPK2 | |
| SCHEMBL24681470 | 0.91 | MAPK1 (0.53) | MAPK1MTORAKT1MAPKAPK2PIK3C3 | |
| SCHEMBL24680816 | 0.91 | MAPK1 (0.53) | MAPK1MTORAKT1MAPKAPK2PIK3C3 | |
| SCHEMBL24680817 | 0.91 | MAPK1 (0.53) | MAPK1MTORAKT1MAPKAPK2PIK3C3 | |
| SCHEMBL29914461 | 0.91 | MAPK1 (0.53) | MAPK1MTORAKT1MAPKAPK2PIK3C3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |