Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | MAP4K1 | Q92918 | 6/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.48 |
| ▸ | ACVRL1 | P37023 | 1/20 | 0.46 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914537 | 0.83 | FYN (0.65) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL24681500 | 0.83 | FYN (0.65) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL29914507 | 0.82 | FYN (0.67) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL24680820 | 0.82 | FYN (0.67) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL2225805 | 0.80 | FYN (0.71) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL2225829 | 0.79 | FYN (1.00) | FYNACVR1TGFBR1LCK | |
| SCHEMBL18613336 | 0.79 | FYN (1.00) | FYNACVR1TGFBR1LCK | |
| SCHEMBL28051294 | 0.78 | RPS6KA3 (0.59) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL27157553 | 0.77 | CHEK1 (0.61) | FYNJAK2CHEK1KDM4EALDH1A1 | |
| SCHEMBL21590290 | 0.76 | MAP4K1 (0.64) | CHEK1MAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |