Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FYN | P06241 | 4/20 | 0.65 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | MAP4K1 | Q92918 | 5/20 | 0.52 |
| ▸ | LCK | P06239 | 1/20 | 0.52 |
| ▸ | MAP4K3 | Q8IVH8 | 1/20 | 0.52 |
| ▸ | ACVR1 | Q04771 | 2/20 | 0.50 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.50 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.49 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.49 |
| ▸ | GFER | P55789 | 1/20 | 0.49 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.49 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24681500 | 1.00 | FYN (0.65) | FYNJAK2MAP4K1LCKMAP4K3 | |
| SCHEMBL24681285 | 0.87 | TGFBR1 (0.52) | FYNJAK2ACVR1TGFBR1 | |
| SCHEMBL29964174 | 0.87 | TGFBR1 (0.52) | FYNJAK2ACVR1TGFBR1 | |
| SCHEMBL29963887 | 0.86 | TGFBR1 (0.54) | FYNJAK2ACVR1TGFBR1KDM4E | |
| SCHEMBL24681609 | 0.85 | FYN (0.49) | FYNJAK2MAP4K1LCKMAP4K3 | |
| SCHEMBL24681088 | 0.85 | DHFR (0.53) | FYNJAK2LCKACVR1TGFBR1 | |
| SCHEMBL29914393 | 0.85 | DHFR (0.53) | FYNJAK2LCKACVR1TGFBR1 | |
| SCHEMBL24681169 | 0.84 | FYN (0.59) | FYNJAK2ACVR1TGFBR1 | |
| SCHEMBL24680752 | 0.83 | FYN (0.65) | FYNJAK2MAP4K1LCKMAP4K3 | |
| SCHEMBL24680820 | 0.82 | FYN (0.67) | FYNJAK2MAP4K1ACVR1TGFBR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |