Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP3K12 | Q12852 | 7/20 | 0.45 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 8/20 | 0.43 |
| ▸ | ACVR1 | Q04771 | 7/20 | 0.43 |
| ▸ | BMPR1B | O00238 | 2/20 | 0.42 |
| ▸ | BMPR1A | P36894 | 2/20 | 0.42 |
| ▸ | ACVRL1 | P37023 | 2/20 | 0.42 |
| ▸ | FYN | P06241 | 3/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914473 | 1.00 | MAP3K12 (0.45) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL29914559 | 1.00 | MAP3K12 (0.45) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL24681263 | 1.00 | MAP3K12 (0.45) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL29914411 | 0.92 | JAK2 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL24681257 | 0.92 | JAK2 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL24681281 | 0.83 | TGFBR1 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL29914577 | 0.83 | TGFBR1 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL24681282 | 0.83 | ACVR1 (0.42) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL24681270 | 0.83 | TGFBR1 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B | |
| SCHEMBL29914448 | 0.83 | TGFBR1 (0.47) | MAP3K12JAK2TGFBR1ACVR1BMPR1B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |