Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAD51 | Q06609 | 3/20 | 0.43 |
| ▸ | DRD4 | P21917 | 1/20 | 0.35 |
| ▸ | NR1H2 | P55055 | 4/20 | 0.35 |
| ▸ | NR1H3 | Q13133 | 4/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.34 |
| ▸ | CHRM5 | P08912 | 1/20 | 0.34 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.34 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.34 |
| ▸ | NOTUM | Q6P988 | 3/20 | 0.34 |
| ▸ | MMP2 | P08253 | 1/20 | 0.34 |
| ▸ | ADAMTS5 | Q9UNA0 | 1/20 | 0.34 |
| ▸ | ACACB | O00763 | 1/20 | 0.34 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | FFAR2 | O15552 | 1/20 | 0.34 |
| ▸ | SLC6A2 | P23975 | 1/20 | 0.33 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.33 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29914582 | 1.00 | RAD51 (0.43) | RAD51DRD4NR1H2NR1H3CHRM2 | |
| SCHEMBL24681541 | 1.00 | RAD51 (0.43) | RAD51DRD4NR1H2NR1H3CHRM2 | |
| SCHEMBL29914426 | 1.00 | RAD51 (0.43) | RAD51DRD4NR1H2NR1H3CHRM2 | |
| SCHEMBL24680805 | 1.00 | RAD51 (0.43) | RAD51DRD4NR1H2NR1H3CHRM2 | |
| SCHEMBL29157654 | 0.88 | NOTUM (0.45) | RAD51DRD4NOTUM | |
| SCHEMBL29157655 | 0.88 | NOTUM (0.45) | RAD51DRD4NOTUM | |
| SCHEMBL24681247 | 0.80 | NOTUM (0.41) | RAD51NOTUMACACBFFAR2 | |
| SCHEMBL24681245 | 0.80 | NOTUM (0.41) | RAD51NOTUMACACBFFAR2 | |
| SCHEMBL24681614 | 0.80 | NOTUM (0.41) | RAD51NOTUMACACBFFAR2 | |
| SCHEMBL24680806 | 0.80 | NR1H2 (0.31) | NR1H2NR1H3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |