Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 8/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.42 |
| ▸ | LMNA | P02545 | 4/20 | 0.42 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | RAD51 | Q06609 | 3/20 | 0.39 |
| ▸ | RAD1 | O60671 | 1/20 | 0.39 |
| ▸ | BCL2A1 | Q16548 | 1/20 | 0.39 |
| ▸ | HTT | P42858 | 6/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | PANK3 | Q9H999 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | DRD2 | P14416 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29157654 | 1.00 | NOTUM (0.45) | NOTUMADRB1DPP4MAPTSMN1; SMN2 | |
| SCHEMBL29914582 | 0.88 | RAD51 (0.43) | NOTUMRAD51DRD4 | |
| SCHEMBL29914426 | 0.88 | RAD51 (0.43) | NOTUMRAD51DRD4 | |
| SCHEMBL24680805 | 0.88 | RAD51 (0.43) | NOTUMRAD51DRD4 | |
| SCHEMBL24680971 | 0.88 | RAD51 (0.43) | NOTUMRAD51DRD4 | |
| SCHEMBL24681541 | 0.88 | RAD51 (0.43) | NOTUMRAD51DRD4 | |
| SCHEMBL24681245 | 0.84 | NOTUM (0.41) | NOTUMADRB1MAPTSMN1; SMN2RAD51 | |
| SCHEMBL24681614 | 0.84 | NOTUM (0.41) | NOTUMADRB1MAPTSMN1; SMN2RAD51 | |
| SCHEMBL24681247 | 0.84 | NOTUM (0.41) | NOTUMADRB1MAPTSMN1; SMN2RAD51 | |
| SCHEMBL8643271 | 0.77 | LMNA (0.47) | NOTUMDPP4MAPTSMN1; SMN2LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117597340-A | Substituted amino-aza-heteroaryl compounds as inhibitors of hematopoietic progenitor kinase 1 (HPK 1) | 安大略省癌症研究所(OICR) | 2024-02-23 | — | — | CN | disclosed |