Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.38 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3R1 | P27986 | 5/20 | 0.37 |
| ▸ | PIK3CA | P42336 | 5/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.37 |
| ▸ | JAK2 | O60674 | 4/20 | 0.36 |
| ▸ | JAK3 | P52333 | 2/20 | 0.36 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | NPY5R | Q15761 | 3/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.34 |
| ▸ | DDR1 | Q08345 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24680787 | 1.00 | PDE10A (0.38) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29914526 | 1.00 | PDE10A (0.38) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29914530 | 1.00 | PDE10A (0.38) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29914606 | 0.84 | PIM1 (0.39) | BTK | |
| SCHEMBL24681116 | 0.84 | PIM1 (0.39) | BTK | |
| SCHEMBL24681006 | 0.81 | NPY5R (0.43) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29914608 | 0.81 | NPY5R (0.43) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL24681623 | 0.81 | NPY5R (0.43) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL29914569 | 0.81 | NPY5R (0.43) | PDE10APIK3CDPIK3R1PIK3CAPIK3CB | |
| SCHEMBL25966654 | 0.81 | HTR2A (0.41) | PIK3CDPIK3R1PIK3CAHTR2AHTR2C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022226667-A1 | SUBSTITUTED AMINO PYRIDINE COMPOUNDS AS INHIBITORS OF THE HAEMATOPOIETIC PROGENITOR KINASE 1 (HPK1) | ONTARIO INSTITUTE FOR CANCER RESEARCH (OICR) (CA) | 2022-11-03 | — | — | WO | disclosed |