Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD17B2 | P37059 | 16/20 | 0.41 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.36 |
| ▸ | HSD17B1 | P14061 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24315871 | 0.74 | EIF4A3 (0.37) | — | |
| SCHEMBL18404761 | 0.74 | HSD17B2 (0.48) | HSD17B2HSD17B1KDM4E | |
| SCHEMBL21871898 | 0.71 | HSD17B2 (0.33) | HSD17B2KDM4E | |
| SCHEMBL14793837 | 0.71 | HMBS (0.43) | KDM4E | |
| SCHEMBL12180269 | 0.71 | DAO (0.39) | KDM4E | |
| SCHEMBL18080473 | 0.70 | NOTUM (0.38) | NOTUMKDM4E | |
| SCHEMBL19372888 | 0.69 | CHEK1 (0.39) | KDM4E | |
| SCHEMBL1686106 | 0.69 | HSD17B2 (0.39) | HSD17B2HSD17B1KDM4E | |
| SCHEMBL26018573 | 0.69 | CHEK1 (0.35) | — | |
| SCHEMBL20204612 | 0.69 | CA1 (0.38) | KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022187518-A1 | SUBSTITUTED 4-PIPERIDINYL-IMIDAZO[4,5-B]PYRIDINES AND RELATED COMPOUNDS AND THEIR USE IN TREATING MEDICAL CONDITIONS | Ikena Oncology, Inc. (US) | 2022-09-09 | — | — | WO | disclosed |