Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LCK | P06239 | 20/20 | 0.61 |
| ▸ | LYN | P07948 | 16/20 | 0.61 |
| ▸ | KDR | P35968 | 16/20 | 0.58 |
| ▸ | SRC | P12931 | 15/20 | 0.58 |
| ▸ | HCK | P08631 | 11/20 | 0.58 |
| ▸ | INSR | P06213 | 13/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470425 | 0.88 | LCK (0.53) | LCKLYNKDRSRCHCK | |
| SCHEMBL2468935 | 0.84 | LCK (0.65) | LCKLYNKDRSRCHCK | |
| SCHEMBL2466473 | 0.82 | LCK (0.62) | LCKLYNKDRSRCHCK | |
| SCHEMBL2465779 | 0.81 | LCK (0.80) | LCKLYNKDRSRCHCK | |
| SCHEMBL2465115 | 0.81 | LCK (0.80) | LCKLYNKDRSRCHCK | |
| SCHEMBL2468051 | 0.79 | LCK (0.61) | LCKLYNKDRSRCHCK | |
| SCHEMBL2466932 | 0.78 | LCK (0.53) | LCKLYNKDRSRCHCK | |
| SCHEMBL2467090 | 0.78 | LCK (0.72) | LCKLYNKDRSRCHCK | |
| SCHEMBL2468692 | 0.77 | LCK (0.62) | LCKLYNKDRSRCHCK | |
| SCHEMBL2467828 | 0.77 | LCK (0.61) | LCKLYNKDRSRCHCK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1899329-B1 | PYRIMIDINE-SUBSTITUTED BENZIMIDAZOLE DERIVATIVES AS PROTEIN KINASE INHIBITORS | IRM LLC (BM) | 2011-10-05 | — | — | EP | claimed |
| US-8426404-B2 | e.g. 3-[1-(6-Amino-pyrimidin-4-yl)-1H-benzoimidazol-2-ylamino]-4-methyl-N-[4-(2-methyl-imidazol-1-yl)-3-trifluoromethyl-phenyl]-benzamide; receptor and non-receptor tyrosine kinases and serine/threonine kinases inhibitor; antiproliferative agent; immune and nervous system disorders | NOVARTIS AG (CH) | 2013-04-23 | — | — | US | disclosed |
| US-20080255112-A1 | Pyrimidine-Substituted Benzimidazole Derivatives as Protein Kinase Inhibitors | IRM LLC (BM) | 2008-10-16 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080255112-A1 | Pyrimidine-Substituted Benzimidazole Derivatives as Protein Kinase Inhibitors | BMX, FYN, BRSK2 | LCK 14/4885LYN 36/4885KDR 175/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.