Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK1 | P23458 | 1/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.44 |
| ▸ | RORC | P51449 | 4/20 | 0.43 |
| ▸ | TSHR | P16473 | 2/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | DPP4 | P27487 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | GPR119 | Q8TDV5 | 3/20 | 0.41 |
| ▸ | MMP13 | P45452 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29995068 | 1.00 | JAK2 (0.44) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL29532756 | 0.84 | RORC (0.46) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL2352484 | 0.84 | RORC (0.46) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL29087345 | 0.83 | JAK2 (0.45) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL29087370 | 0.82 | TSHR (0.47) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL13404311 | 0.81 | TACR1 (0.48) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL29087380 | 0.80 | RORC (0.45) | RORCGPR119MMP13 | |
| SCHEMBL29995104 | 0.80 | RORC (0.45) | RORCGPR119MMP13 | |
| SCHEMBL27225781 | 0.80 | JAK2 (0.47) | JAK2JAK1TACR1RORCTSHR | |
| SCHEMBL2430889 | 0.80 | RORC (0.48) | JAK2JAK1TACR1RORCHDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116806217-A | Substituted cyclic modulators of protein phosphatase 2A (PP 2A) and methods of use thereof | 拉帕塔疗法公司 | 2023-09-26 | — | — | CN | disclosed |
| WO-2022167867-A1 | SUBSTITUTED CYCLIC MODULATORS OF PROTEIN PHOSPHATASE 2A (PP2A) AND METHODS USING SAME | RAPPTA THERAPEUTICS OY (FI) | 2022-08-11 | — | — | WO | disclosed |