Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 10/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 10/20 | 0.82 |
| ▸ | PKM | P14618 | 9/20 | 0.82 |
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.82 |
| ▸ | HPGD | P15428 | 7/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 6/20 | 0.82 |
| ▸ | MAPT | P10636 | 8/20 | 0.76 |
| ▸ | MEN1 | O00255 | 6/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.76 |
| ▸ | LMNA | P02545 | 6/20 | 0.70 |
| ▸ | TSHR | P16473 | 5/20 | 0.70 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.70 |
| ▸ | ALOX12 | P18054 | 4/20 | 0.70 |
| ▸ | CTDSP1 | Q9GZU7 | 3/20 | 0.70 |
| ▸ | ALOX15 | P16050 | 3/20 | 0.70 |
| ▸ | CASP1 | P29466 | 2/20 | 0.70 |
| ▸ | CASP7 | P55210 | 2/20 | 0.70 |
| ▸ | TDP1 | Q9NUW8 | 5/20 | 0.67 |
| ▸ | MCL1 | Q07820 | 2/20 | 0.67 |
| ▸ | HTT | P42858 | 1/20 | 0.67 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30102527 | 1.00 | POLB (0.82) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL24688399 | 0.85 | CHEK1 (0.85) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL30102533 | 0.85 | CHEK1 (0.85) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL24688076 | 0.85 | POLB (0.82) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL30102535 | 0.85 | POLB (0.82) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL24688074 | 0.85 | RXFP1 (0.73) | ALDH1A1KDM4EHPGDL3MBTL1MAPT | |
| SCHEMBL30102560 | 0.85 | RXFP1 (0.73) | ALDH1A1KDM4EHPGDL3MBTL1MAPT | |
| SCHEMBL12839882 | 0.84 | POLB (0.80) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL13210537 | 0.82 | ALDH1A1 (0.72) | POLBALDH1A1PKMKDM4EHPGD | |
| SCHEMBL24688075 | 0.81 | CYP3A4 (0.74) | ALDH1A1KDM4EL3MBTL1KMT2ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4089077-A1 | NOVEL QUINOLINE DERIVATIVES AND USES THEREOF | Istituto Europeo di Oncologia S.r.l. (IT) | 2022-11-16 | — | — | EP | disclosed |