Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MET | P08581 | 18/20 | 0.56 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.43 |
| ▸ | NEK2 | P51955 | 1/20 | 0.43 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.43 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.43 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2469419 | 0.95 | MET (0.56) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2492364 | 0.95 | MET (0.60) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2491089 | 0.91 | MET (0.59) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2468145 | 0.91 | MET (0.45) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2496076 | 0.86 | MET (0.47) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2469391 | 0.86 | MET (0.48) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2673295 | 0.86 | MET (0.60) | MET | |
| SCHEMBL2497392 | 0.86 | MET (0.56) | METCHEK1NEK2LIMK1TYRO3 | |
| SCHEMBL2464380 | 0.84 | MET (0.63) | MET | |
| SCHEMBL2468334 | 0.84 | MET (0.63) | MET |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1960370-B1 | PYRIDIAZINONE DERIVATIVES FOR TUMOUR TREATMENT | MERCK PATENT GMBH (DE) | 2011-10-05 | — | — | EP | claimed |