Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 6/20 | 0.62 |
| ▸ | ROCK1 | Q13464 | 6/20 | 0.62 |
| ▸ | NPC1 | O15118 | 6/20 | 0.54 |
| ▸ | RAB9A | P51151 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK1 | P23458 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | DHODH | Q02127 | 1/20 | 0.52 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.51 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.51 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.51 |
| ▸ | CLK2 | P49760 | 1/20 | 0.51 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.51 |
| ▸ | PRKG1 | Q13976 | 1/20 | 0.51 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.51 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.51 |
| ▸ | SGK2 | Q9HBY8 | 1/20 | 0.51 |
| ▸ | STK17A | Q9UEE5 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15934021 | 0.83 | ROCK2 (0.53) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL17776529 | 0.82 | ROCK2 (0.71) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL20611859 | 0.81 | ROCK2 (0.64) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL10310329 | 0.80 | ROCK2 (0.63) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL2572294 | 0.79 | ROCK2 (0.66) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL23075124 | 0.77 | CNR1 (0.69) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL2565558 | 0.77 | ROCK2 (1.00) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL12257075 | 0.76 | JAK2 (0.60) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL21341425 | 0.76 | ROCK2 (0.58) | ROCK2ROCK1NPC1RAB9AMEN1 | |
| SCHEMBL4501257 | 0.76 | ROCK2 (0.66) | ROCK2ROCK1NPC1RAB9AMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3421465-B1 | RHO-ASSOCIATED PROTEIN KINASE INHIBITOR, PHARMACEUTICAL COMPOSITION COMPRISING THE SAME, AS WELL AS PREPARATION METHOD AND USE THEREOF | BEIJING TIDE PHARMACEUTICAL CO LTD (CN) | 2022-10-26 | — | — | EP | disclosed |