Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.31 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.31 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | CASP7 | P55210 | 1/20 | 0.31 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24697183 | 0.81 | KHK (0.38) | — | |
| SCHEMBL24696669 | 0.77 | CYP3A4 (0.41) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL13147636 | 0.76 | TSHR (0.48) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL21693757 | 0.75 | KDM4E (0.49) | TSHRCYP3A4MAPTKDM4EHSD17B10 | |
| SCHEMBL7024058 | 0.74 | TSHR (0.52) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL22401233 | 0.73 | KDM4E (0.49) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL10289771 | 0.73 | KDM4E (0.49) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL19598684 | 0.72 | CYP3A4 (0.50) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL1771090 | 0.71 | TSHR (0.42) | TSHRCYP3A4MAPK1MAPTTDP1 | |
| SCHEMBL29509774 | 0.71 | TSHR (0.42) | TSHRCYP3A4MAPK1MAPTTDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022254027-A1 | 3-PYRROLYLSULFONAMIDE COMPOUNDS AS GPR17 ANTAGONISTS | REWIND THERAPEUTICS NV (BE) | 2022-12-08 | — | — | WO | disclosed |