Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 3/20 | 0.40 |
| ▸ | FEN1 | P39748 | 3/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | KHK | P50053 | 1/20 | 0.34 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.34 |
| ▸ | BACE1 | P56817 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH2 | P05091 | 1/20 | 0.30 |
| ▸ | GLA | P06280 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30892370 | 1.00 | ALOX5AP (0.40) | ALOX5APFEN1SYKPOLBHTT | |
| SCHEMBL18125543 | 0.77 | CYP11B1 (0.42) | SYKCYP11B1CYP11B2ALDH1A1HSD17B10 | |
| SCHEMBL30723523 | 0.75 | APP (0.38) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL23641450 | 0.75 | APP (0.38) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL29778756 | 0.74 | SCN5A (0.34) | BACE1 | |
| SCHEMBL23641255 | 0.74 | SCN5A (0.34) | BACE1 | |
| SCHEMBL18125382 | 0.72 | CA12 (0.37) | SMN1; SMN2 | |
| SCHEMBL12563479 | 0.72 | TAAR1 (0.42) | ALOX5APFEN1CYP11B1CYP11B2BACE1 | |
| SCHEMBL15547729 | 0.71 | SYK (0.41) | ALOX5APFEN1SYKPOLBCYP11B1 | |
| SCHEMBL25343506 | 0.71 | PARP10 (0.43) | ALOX5APFEN1BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117794898-A | 3-pyrrolylsulfonamide compounds as GPR17 antagonists | 瑞文德医疗公众有限公司 | 2024-03-29 | — | — | CN | disclosed |
| WO-2022254027-A1 | 3-PYRROLYLSULFONAMIDE COMPOUNDS AS GPR17 ANTAGONISTS | REWIND THERAPEUTICS NV (BE) | 2022-12-08 | — | — | WO | disclosed |