Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | APP | P05067 | 3/20 | 0.38 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.37 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | RXRA | P19793 | 2/20 | 0.34 |
| ▸ | GRIN1 | Q05586 | 2/20 | 0.34 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.34 |
| ▸ | AKT1 | P31749 | 3/20 | 0.33 |
| ▸ | HTR2A | P28223 | 2/20 | 0.33 |
| ▸ | HTR2C | P28335 | 2/20 | 0.33 |
| ▸ | HTR2B | P41595 | 2/20 | 0.33 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.33 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.33 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.33 |
| ▸ | PIM1 | P11309 | 2/20 | 0.33 |
| ▸ | PRKACA | P17612 | 2/20 | 0.33 |
| ▸ | CLK2 | P49760 | 2/20 | 0.33 |
| ▸ | PRKX | P51817 | 2/20 | 0.33 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30723523 | 1.00 | APP (0.38) | APPCYP11B1CYP11B2MAPTRXRA | |
| SCHEMBL18125543 | 0.79 | CYP11B1 (0.42) | CYP11B1CYP11B2MAPT | |
| SCHEMBL29778756 | 0.76 | SCN5A (0.34) | APPBACE1 | |
| SCHEMBL23641255 | 0.76 | SCN5A (0.34) | APPBACE1 | |
| SCHEMBL30892370 | 0.75 | ALOX5AP (0.40) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL24696642 | 0.75 | ALOX5AP (0.40) | CYP11B1CYP11B2BACE1 | |
| SCHEMBL18125382 | 0.75 | CA12 (0.37) | MAPTHTR2AHTR2CHTR2BSLC6A4 | |
| SCHEMBL12563479 | 0.75 | TAAR1 (0.42) | CYP11B1CYP11B2MAP4K4BACE1 | |
| SCHEMBL25343506 | 0.74 | PARP10 (0.43) | BACE1 | |
| SCHEMBL29457442 | 0.74 | PARP10 (0.43) | BACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | UCB PHARMA GMBH (DE) | 2024-05-07 | — | — | US | disclosed |
| CN-112292375-B | Substituted alkoxypyridinyl indole sulfonamides | 优时比制药有限公司 | 2023-12-05 | — | — | CN | disclosed |
| EP-4086248-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB Pharma GmbH (DE) | 2022-11-09 | — | — | EP | disclosed |
| EP-3810587-B1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2022-08-10 | — | — | EP | disclosed |
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | UCB PHARMA GMBH (DE) | 2021-07-15 | — | — | US | disclosed |
| CN-112292375-A | Substituted alkoxypyridylindolesulfonamides | 优时比制药有限公司 | 2021-01-29 | — | — | CN | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210214337-A1 | SUBSTITUTED ALKOXYPYRIDINYL INDOLSULFONAMIDES | GPR119, GPR17, GPR27 | APP 1935/4885CYP11B1 194/4885CYP11B2 193/4885 |
| US-11976056-B2 | Substituted alkoxypyridinyl indolsulfonamides | GPR119, GPR17, GPR27 | APP 1935/4885CYP11B1 194/4885CYP11B2 193/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.