SCHEMBL24697188

SCHEMBL24697188

CCCC(CCC)C(=O)N[C@@H]1CCN(C)C1

nearest known ligand 0.45

Predicted protein targets (top 19)

geneUniProtsupporting neighboursconfidence
HDAC7 Q8WUI4 1/20 0.43
HDAC8 Q9BY41 1/20 0.43
HDAC6 Q9UBN7 1/20 0.43
HDAC9 Q9UKV0 1/20 0.43
HDAC5 Q9UQL6 1/20 0.43
TSHR P16473 1/20 0.41
SSTR4 P31391 9/20 0.41
SSTR1 P30872 6/20 0.41
CA12 O43570 2/20 0.40
CA1 P00915 2/20 0.40
CA2 P00918 2/20 0.40
CA7 P43166 2/20 0.40
CA9 Q16790 2/20 0.40
CA14 Q9ULX7 2/20 0.40
SMN1; SMN2 Q16637 1/20 0.39
SIGMAR1 Q99720 1/20 0.38
USP2 O75604 1/20 0.36
MME P08473 1/20 0.36
KDM4E B2RXH2 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21730511 0.87 USP2 (0.42) HDAC7HDAC8HDAC6HDAC9HDAC5
SCHEMBL355760 0.81 CHRNB4 (0.48) SSTR4SSTR1SIGMAR1KDM4E
SCHEMBL25144361 0.80 SIGMAR1 (0.44) SSTR4SSTR1CA1CA2SIGMAR1
SCHEMBL18347953 0.80 KDM5A (0.45) SSTR4SSTR1KDM4E
SCHEMBL16078081 0.80 KDM5A (0.45) SSTR4SSTR1KDM4E
SCHEMBL13192995 0.80 KDM5A (0.45) SSTR4SSTR1KDM4E
SCHEMBL23584108 0.79 SIGMAR1 (0.46) CA1CA2SIGMAR1USP2
SCHEMBL18949684 0.78 KDM4E (0.44) TSHRSSTR4SIGMAR1USP2KDM4E
SCHEMBL13576336 0.78 DPP4 (0.38) SSTR4SSTR1SMN1; SMN2SIGMAR1KDM4E
SCHEMBL21695552 0.78 SMN1; SMN2 (0.47) HDAC7HDAC8HDAC6HDAC9HDAC5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3412663-B1 NITROGEN-CONTAINING HETEROCYCLE AND CARBOCYCLE DERIVATIVES HAVING TRKA INHIBITORY ACTIVITY SHIONOGI & CO (JP) 2022-09-07 EP disclosed