Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 10/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.49 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.49 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.49 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | SYK | P43405 | 3/20 | 0.43 |
| ▸ | BTK | Q06187 | 3/20 | 0.43 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.40 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1822986 | 0.84 | PIK3CA (0.78) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2469890 | 0.83 | PIK3CA (0.58) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1820136 | 0.74 | PIK3CA (0.52) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL28650466 | 0.74 | ROCK2 (0.66) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL2466213 | 0.74 | PIK3CA (0.77) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1310062 | 0.73 | ROCK2 (0.51) | PIK3CAPIK3CDPIK3CBPIK3CGPLK4 | |
| SCHEMBL2466064 | 0.73 | PIK3CA (0.50) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1820789 | 0.72 | PIK3CA (0.82) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1821363 | 0.72 | PIK3CA (1.00) | PIK3CAPIK3CDPIK3CBPIK3CGROCK2 | |
| SCHEMBL1311233 | 0.72 | GRIA1 (0.52) | PIK3CAPIK3CDPIK3CGROCK2ROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1575940-B1 | 2,4,6-TRISUBSTITUTED PYRIMIDINES AS PHOSPHOTIDYLINOSITOL (PI) 3-KINASE INHIBITORS AND THEIR USE IN THE TREATMENT OF CANCER | NOVARTIS AG (CH) | 2011-10-05 | — | — | EP | disclosed |