Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 3/20 | 0.36 |
| ▸ | EGLN2 | Q96KS0 | 2/20 | 0.35 |
| ▸ | HTR2A | P28223 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | MAOB | P27338 | 1/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | RECQL | P46063 | 1/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | FASN | P49327 | 2/20 | 0.31 |
| ▸ | KDM1A | O60341 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.31 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.31 |
| ▸ | POLB | P06746 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015886 | 1.00 | HRH3 (0.36) | HRH3EGLN2HTR2AHTR2CHTR2B | |
| SCHEMBL29134822 | 0.86 | MTOR (0.41) | HRH3RECQLMTORSMN1; SMN2POLB | |
| SCHEMBL30014710 | 0.86 | MTOR (0.41) | HRH3RECQLMTORSMN1; SMN2POLB | |
| SCHEMBL24698381 | 0.86 | MTOR (0.41) | HRH3RECQLMTORSMN1; SMN2POLB | |
| SCHEMBL24698482 | 0.83 | HRH3 (0.35) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL24699080 | 0.82 | TDP1 (0.39) | HRH3EGLN2HTR2AHTR2CHTR2B | |
| SCHEMBL30015974 | 0.82 | TDP1 (0.39) | HRH3EGLN2HTR2AHTR2CHTR2B | |
| SCHEMBL24697557 | 0.77 | HRH3 (0.39) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL24699438 | 0.77 | HRH3 (0.49) | HRH3MTORPDK1PDK2PDK3 | |
| SCHEMBL30015449 | 0.77 | HRH3 (0.39) | HRH3PDK1PDK2PDK3PDK4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |