Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 5/20 | 0.34 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.34 |
| ▸ | EGLN2 | Q96KS0 | 1/20 | 0.34 |
| ▸ | HTR2A | P28223 | 1/20 | 0.33 |
| ▸ | HTR2C | P28335 | 1/20 | 0.33 |
| ▸ | HTR2B | P41595 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.33 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | HTR6 | P50406 | 1/20 | 0.32 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.32 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.32 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.32 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30015974 | 1.00 | TDP1 (0.39) | TDP1HSD11B1HRH3EGLN2HTR2A | |
| SCHEMBL24699256 | 0.90 | MEN1 (0.37) | HRH3SMN1; SMN2PDK1PDK2PDK3 | |
| SCHEMBL30014670 | 0.88 | KCNK3 (0.34) | TDP1HSD11B1EGLN2HTR2AHTR2C | |
| SCHEMBL24697985 | 0.88 | KCNK3 (0.34) | TDP1HSD11B1EGLN2HTR2AHTR2C | |
| SCHEMBL24699243 | 0.88 | KDM1A (0.33) | TDP1HRH3PDK1PDK2PDK3 | |
| SCHEMBL30016531 | 0.85 | PI4KB (0.36) | TDP1HRH3EGLN2HTR2AHTR2C | |
| SCHEMBL24697976 | 0.85 | PI4KB (0.36) | TDP1HRH3EGLN2HTR2AHTR2C | |
| SCHEMBL30015473 | 0.84 | MTOR (0.36) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL24698349 | 0.84 | MTOR (0.36) | HRH3PDK1PDK2PDK3PDK4 | |
| SCHEMBL24698381 | 0.84 | MTOR (0.41) | HRH3CYP3A4TSHRSMN1; SMN2MTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |