Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.35 |
| ▸ | HRH2 | P25021 | 5/20 | 0.35 |
| ▸ | SMO | Q99835 | 1/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.34 |
| ▸ | KDM1A | O60341 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 2/20 | 0.32 |
| ▸ | MTOR | P42345 | 1/20 | 0.32 |
| ▸ | EEF2K | O00418 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | PDE2A | O00408 | 1/20 | 0.32 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24698766 | 1.00 | HRH3 (0.35) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698714 | 0.89 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698818 | 0.89 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698712 | 0.89 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698713 | 0.89 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698716 | 0.89 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24697597 | 0.88 | HRH2 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24697789 | 0.88 | ALDH1A1 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698865 | 0.88 | HRH2 (0.36) | HRH3HRH2SMOALDH1A1KDM1A | |
| SCHEMBL24698718 | 0.88 | HRH3 (0.36) | HRH3HRH2SMOALDH1A1KDM1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4313967-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2024-02-07 | — | — | EP | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |