Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3A | P49840 | 1/20 | 0.53 |
| ▸ | GSK3B | P49841 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 11/20 | 0.44 |
| ▸ | PDPK1 | O15530 | 6/20 | 0.44 |
| ▸ | UHRF1 | Q96T88 | 1/20 | 0.42 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | AURKA | O14965 | 1/20 | 0.41 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.41 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.41 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.41 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | TYK2 | P29597 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1640905 | 0.86 | PDPK1 (0.46) | GSK3AGSK3BJAK2PDPK1UHRF1 | |
| SCHEMBL7920977 | 0.82 | ADORA2A (0.47) | GSK3AGSK3BUHRF1DYRK1A | |
| SCHEMBL15542652 | 0.79 | JAK2 (0.40) | GSK3AGSK3BJAK2UHRF1DYRK1A | |
| SCHEMBL5826761 | 0.79 | GSK3A (0.64) | GSK3AGSK3BJAK2PDPK1AURKA | |
| SCHEMBL12481324 | 0.78 | PIM1 (0.33) | GSK3AGSK3BUHRF1DYRK1A | |
| SCHEMBL12479452 | 0.78 | UHRF1 (0.36) | GSK3AGSK3BJAK2PDPK1UHRF1 | |
| SCHEMBL31317680 | 0.78 | UHRF1 (0.36) | GSK3AGSK3BJAK2PDPK1UHRF1 | |
| SCHEMBL12480568 | 0.77 | PRKAG1 (0.38) | GSK3AGSK3BJAK2DYRK1AKDM4E | |
| SCHEMBL16517125 | 0.77 | PRKAG1 (0.47) | — | |
| SCHEMBL17514104 | 0.76 | JAK2 (0.53) | GSK3AGSK3BJAK2PDPK1DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022212194-A1 | KHK INHIBITORS | GILEAD SCIENCES, INC. (US) | 2022-10-06 | — | — | WO | disclosed |