Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | P2RX1 | P51575 | 3/20 | 0.38 |
| ▸ | P2RX3 | P56373 | 3/20 | 0.38 |
| ▸ | P2RX4 | Q99571 | 2/20 | 0.38 |
| ▸ | P2RY1 | P47900 | 6/20 | 0.37 |
| ▸ | P2RY2 | P41231 | 2/20 | 0.37 |
| ▸ | P2RX2 | Q9UBL9 | 2/20 | 0.37 |
| ▸ | SRC | P12931 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MACROD2 | A1Z1Q3 | 1/20 | 0.35 |
| ▸ | SIRT6 | Q8N6T7 | 1/20 | 0.35 |
| ▸ | MACROD1 | Q9BQ69 | 1/20 | 0.35 |
| ▸ | TRPM2 | O94759 | 1/20 | 0.35 |
| ▸ | POLRMT | O00411 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17129820 | 0.94 | P2RX1 (0.43) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL17129815 | 0.94 | P2RX1 (0.43) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL24700204 | 0.90 | P2RX1 (0.37) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL15682900 | 0.88 | P2RX1 (0.43) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL17525235 | 0.88 | P2RX1 (0.43) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL24700004 | 0.86 | P2RX1 (0.41) | P2RX1P2RX3P2RX4P2RY1P2RX2 | |
| SCHEMBL17129812 | 0.85 | P2RX1 (0.42) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL17129837 | 0.85 | P2RX1 (0.42) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL17124612 | 0.84 | P2RX1 (0.38) | P2RX1P2RX3P2RX4P2RY1P2RY2 | |
| SCHEMBL17129823 | 0.83 | POLRMT (0.47) | P2RX1P2RX3P2RX4P2RX2POLRMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2909209-B1 | 2'-CYANO SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHODS OF USE THEREOF FOR TREATMENT OF VIRAL DISEASES | MERCK SHARP & DOHME LLC (US) | 2022-08-03 | — | — | EP | disclosed |