Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIRT2 | Q8IXJ6 | 13/20 | 0.64 |
| ▸ | NMBR | P28336 | 1/20 | 0.44 |
| ▸ | MDM4 | O15151 | 1/20 | 0.43 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2470129 | 1.00 | SIRT2 (0.64) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL10026711 | 0.90 | SIRT2 (0.64) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL4246949 | 0.90 | SIRT2 (0.67) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL2476152 | 0.88 | SIRT2 (0.52) | SIRT2NMBR | |
| SCHEMBL2476149 | 0.88 | SIRT2 (0.52) | SIRT2NMBR | |
| SCHEMBL18715386 | 0.86 | SIRT2 (0.67) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL2473099 | 0.85 | SIRT2 (0.64) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL2473101 | 0.85 | SIRT2 (0.64) | SIRT2NMBRMDM4MDM2HDAC6 | |
| SCHEMBL19512096 | 0.85 | SIRT2 (0.59) | SIRT2NMBRMDM4MDM2MEN1 | |
| SCHEMBL12626396 | 0.85 | SIRT2 (0.66) | SIRT2NMBRMDM4MDM2HDAC6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2371421-A1 | Ligands of insulin degrading enzyme and their uses | Université de Lille 2 Droit et Santé (FR) | 2011-10-05 | — | — | EP | disclosed |
| WO-2011107948-A2 | LIGANDS OF INSULIN DEGRADING ENZYME AND THEIR USES | UNIVERSITE LILLE 2 DROIT ET SANTE (FR) | 2011-09-09 | — | — | WO | disclosed |