Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 2/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.36 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22637134 | 0.78 | DYRK1A (0.38) | HTTKDM4EALDH1A1L3MBTL1HPGD | |
| SCHEMBL5162783 | 0.76 | SMN1; SMN2 (0.38) | HTTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL13450919 | 0.76 | CHRM2 (0.62) | KDM4EALDH1A1L3MBTL1MEN1KMT2A | |
| SCHEMBL31706588 | 0.75 | SIRT2 (0.38) | KDM4EALDH1A1L3MBTL1HTR2AHTR2C | |
| SCHEMBL15104527 | 0.75 | L3MBTL1 (0.45) | HTTKDM4EALDH1A1L3MBTL1MEN1 | |
| SCHEMBL12434098 | 0.74 | KDM4E (0.37) | KDM4EALDH1A1MEN1KMT2ASMN1; SMN2 | |
| SCHEMBL17847863 | 0.74 | KCNH2 (0.40) | KDM4EALDH1A1MEN1KMT2AHTR2A | |
| SCHEMBL1048028 | 0.74 | KDM4E (0.37) | HTTKDM4EALDH1A1L3MBTL1KMT2A | |
| SCHEMBL26686762 | 0.74 | LRRK2 (0.50) | KDM4EALDH1A1MEN1KMT2AHPGD | |
| SCHEMBL29186948 | 0.73 | S1PR1 (0.36) | HTTKDM4EMEN1KMT2AMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117813302-A | Substituted tetrahydrofuran-2-carboxamides as sodium channel modulators | 沃泰克斯药物股份有限公司 | 2024-04-02 | — | — | CN | disclosed |
| WO-2022256702-A1 | SUBSTITUTED TETRAHYDROFURAN-2-CARBOXAMIDES AS MODULATORS OF SODIUM CHANNELS | VERTEX PHARMACEUTICALS INCORPORATED (US) | 2022-12-08 | — | — | WO | disclosed |