Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RET | P07949 | 2/20 | 0.74 |
| ▸ | SRC | P12931 | 16/20 | 0.59 |
| ▸ | PIK3CD | O00329 | 13/20 | 0.59 |
| ▸ | ABL1 | P00519 | 13/20 | 0.59 |
| ▸ | EGFR | P00533 | 13/20 | 0.59 |
| ▸ | KDR | P35968 | 13/20 | 0.59 |
| ▸ | PIK3CA | P42336 | 13/20 | 0.59 |
| ▸ | PRKDC | P78527 | 13/20 | 0.59 |
| ▸ | PI4KB | Q9UBF8 | 13/20 | 0.59 |
| ▸ | HCK | P08631 | 12/20 | 0.59 |
| ▸ | MTOR | P42345 | 12/20 | 0.59 |
| ▸ | EPHB4 | P54760 | 12/20 | 0.59 |
| ▸ | PIK3CG | P48736 | 12/20 | 0.59 |
| ▸ | PIK3CB | P42338 | 11/20 | 0.59 |
| ▸ | AURKA | O14965 | 1/20 | 0.52 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.52 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.52 |
| ▸ | BACE1 | P56817 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24710401 | 0.94 | RET (0.72) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710402 | 0.94 | RET (0.71) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710400 | 0.93 | RET (0.74) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710409 | 0.92 | RET (0.82) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710742 | 0.92 | RET (0.69) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710712 | 0.92 | RET (0.89) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL31000867 | 0.92 | RET (0.89) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710403 | 0.90 | RET (0.71) | RETSRCPIK3CDABL1EGFR | |
| Trifluoroacetic Acid SCHEMBL30155338 | 0.89 | RET (0.77) | RETSRCPIK3CDABL1EGFR | |
| SCHEMBL24710735 | 0.87 | RET (0.67) | RETSRCPIK3CDABL1EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2022261352-A1 | PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-15 | — | — | WO | disclosed |
| WO-2022261352-A1 | PERFLUOROALKANE SUBSTITUTED PYRAZOLO[3,4-D]PYRIMIDIN AND PYRROLO[2,3-D]PYRIMIDIN COMPOUNDS AND USES THEREOF | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2022-12-15 | — | — | WO | disclosed |