Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Chloroprocaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.57 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.57 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.57 |
| ▸ | MAOA | P21397 | 4/20 | 0.82 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.82 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.82 |
| ▸ | HTR3A | P46098 | 3/20 | 0.82 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.82 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.82 |
| ▸ | HTR2C | P28335 | 1/20 | 0.82 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.82 |
| ▸ | CYP2D6 | P10635 | 6/20 | 0.69 |
| ▸ | TSHR | P16473 | 5/20 | 0.69 |
| ▸ | BLM | P54132 | 1/20 | 0.67 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.67 |
| ▸ | CYP1A2 | P05177 | 7/20 | 0.57 |
| ▸ | CYP3A4 | P08684 | 5/20 | 0.53 |
| ▸ | LMNA | P02545 | 5/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.52 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Chloroprocaine SCHEMBL28104711 | 0.97 | HRH3 (0.88) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL6676 | 0.91 | HRH3 (1.00) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL29354179 | 0.91 | HRH3 (1.00) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL21612249 | 0.90 | HRH3 (0.97) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL1650786 | 0.90 | HRH3 (0.97) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL24096 | 0.90 | HRH3 (0.97) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Procaine SCHEMBL11895745 | 0.87 | CYP2D6 (0.91) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL6272449 | 0.84 | HRH3 (0.86) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Propoxycaine SCHEMBL8683800 | 0.84 | CYP1A2 (0.83) | MAOAHRH3KCNH2HTR3ACHRM2 | |
| Chloroprocaine SCHEMBL3808985 | 0.83 | HRH3 (0.80) | MAOAHRH3KCNH2HTR3ACHRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9005634-B2 | Shelf stable pharmaceutical depot | MEDTRONIC, INC. (US) | 2015-04-14 | — | — | US | disclosed |
| US-8822546-B2 | Flowable pharmaceutical depot | MEDTRONIC, INC. (US) | 2014-09-02 | — | — | US | disclosed |
| US-20120263761-A1 | SHELF STABLE PHARMACEUTICAL DEPOT | WARSAW ORTHOPEDIC, INC. (US) | 2012-10-18 | — | — | US | disclosed |
| WO-2011133370-A1 | SHELF STABLE PHARMACEUTICAL DEPOT | MEDTRONIC, INC. (US) | 2011-10-27 | — | — | WO | disclosed |
| EP-2370063-A2 | FLOWABLE PHARMACEUTICAL DEPOT | Medtronic, Inc. (US) | 2011-10-05 | — | — | EP | disclosed |
| WO-2010065456-A2 | FLOWABLE PHARMACEUTICAL DEPOT | MEDTRONIC, INC. (US) | 2010-06-10 | — | — | WO | disclosed |
| US-20100137369-A1 | FLOWABLE PHARMACEUTICAL DEPOT | MEDTRONIC, INC. (US) | 2010-06-03 | — | — | US | disclosed |