Known targets — ChEMBL curated mechanism
SCN10ASCN11ASCN1ASCN2ASCN3ASCN4ASCN5ASCN7ASCN8ASCN9A
The experimentally established mechanism targets of Procaine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN1A known ✓ | P35498 | 5/20 | 0.68 |
| ▸ | SCN2A known ✓ | Q99250 | 5/20 | 0.68 |
| ▸ | SCN3A known ✓ | Q9NY46 | 5/20 | 0.68 |
| ▸ | CYP2D6 | P10635 | 5/20 | 0.91 |
| ▸ | MAOA | P21397 | 4/20 | 0.91 |
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.91 |
| ▸ | TSHR | P16473 | 4/20 | 0.91 |
| ▸ | HTR3A | P46098 | 2/20 | 0.91 |
| ▸ | BLM | P54132 | 1/20 | 0.89 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.89 |
| ▸ | CYP1A2 | P05177 | 6/20 | 0.71 |
| ▸ | LMNA | P02545 | 5/20 | 0.71 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.71 |
| ▸ | PHLPP2 | Q6ZVD8 | 1/20 | 0.66 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 2/20 | 0.62 |
| ▸ | SLC6A3 | Q01959 | 2/20 | 0.62 |
| ▸ | HTR1A | P08908 | 1/20 | 0.62 |
| ▸ | GAA | P10253 | 1/20 | 0.62 |
| ▸ | DRD3 | P35462 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Procaine SCHEMBL3524 | 0.95 | CYP2D6 (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL3731588 | 0.94 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL6061234 | 0.94 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL28977033 | 0.94 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL11047275 | 0.94 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL6901191 | 0.94 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL27720 | 0.94 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL3422994 | 0.94 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL5311049 | 0.94 | BLM (1.00) | CYP2D6MAOAHRH3TSHRHTR3A | |
| Procaine SCHEMBL9050778 | 0.94 | CYP2D6 (0.97) | CYP2D6MAOAHRH3TSHRHTR3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150010603-A1 | FILLER COMPRISING BEADS | MERZ PHARMA GMBH & CO KGAA (DE) | 2015-01-08 | — | — | US | claimed |
| US-20140377368-A1 | CHITOSAN BEADS AND FILLER COMPRISING SUCH BEADS | MERZ PHARMA GMBH & CO KGAA (DE) | 2014-12-25 | — | — | US | claimed |
| US-10869818-B2 | Foamable skin composition | PARAGON NORDIC AB (SE) | 2020-12-22 | — | — | US | disclosed |
| US-20190142710-A1 | FOAMABLE SKIN COMPOSITION | PARAGON NORDIC AB (SE) | 2019-05-16 | — | — | US | disclosed |
| EP-3482742-A1 | FOAMABLE SKIN COMPOSITION | Paragon Nordic AB (SE) | 2019-05-15 | — | — | EP | disclosed |
| US-20170189539-A1 | COMPOSITION HAVING IMPROVED SPRAYING CHARACTERISTICS COMPRISING VEGETABLE OILS AND TRIGLYCERIDES AND/OR MINERAL OILS | PARAGON NORDIC AB (SE) | 2017-07-06 | — | — | US | disclosed |
| EP-3142703-A1 | COMPOSITION HAVING IMPROVED SPRAYING CHARACTERISTICS COMPRISING VEGETABLE OILS AND TRIGLYCERIDES AND/OR MINERAL OILS | Paragon Nordic AB (SE) | 2017-03-22 | — | — | EP | disclosed |
| US-20160058752-A1 | TOPICAL PERIPHERAL NEURO-AFFECTIVE (TPNA) THERAPY FOR NEUROPATHIC CONDITIONS | AFGIN PHARMA, LLC (US) | 2016-03-03 | — | — | US | disclosed |
| WO-2015174910-A1 | COMPOSITION HAVING IMPROVED SPRAYING CHARACTERISTICS COMPRISING VEGETABLE OILS AND TRIGLYCERIDES AND/OR MINERAL OILS | AEROSOL SCANDINAVIA AB (SE) | 2015-11-19 | — | — | WO | disclosed |
| US-20120195954-A1 | Method of Reducing Appetite | ROXITICUS HEALTH PRODUCTS, LLC (US) | 2012-08-02 | — | — | US | disclosed |